Without going into the details of the functions of the endocrine glands, one may say that they are "the managers of the human body." Every individual, from the time he is born until the time he dies, is under the influence of these many different kinds of elements,--some of them having to do with the development of the bones and teeth, some with the development of the body and nervous system, some with the development of the mind, etc. (and character), and later on with reproduction. These glands are not independent of one another but interact in a marvelous manner so that under or overaction of any one of them upsets a balance that exists between them, and thus produces a disorder that is quite generalized in its effects. The work on this subject is a tribute to medicine and one pauses in respect and admiration before the names and labors of Brown, Sequard, Addison, Graves and Basedow, Horsley, King, Schiff, Schafer, Takamine, Marie, Cushing, Kendal, Sajous and others of equal insight and patient endeavor.
But let us pass over to the specific instances that bear on our thesis, to wit, that mind and character are functions of the organism and have their seat not only in the brain but in the entire organism.
How do the endocrines prove this? As well as they prove that physical growth and the growth of the secondary sex characters are dependent on these glands. Take diseases of the thyroid gland as the first and shining example.
The thyroid secretes a substance which substantially is an "iodized globulin,"--and which can be separated from the gland products. This secretion has the main effect of "activating metabolism" (Vassale and Generali); in ordinary phrase it acts to increase the discharge of energy of the cells of the body. In all living things there is a twofold process constantly going on: first the building up of energy by means of the foodstuffs, air and water taken in, and second a discharge of energy in the form of heat, motion and--in my belief --emotion and thought itself, though this would be denied by many psychologists. Yet how escape this conclusion from the following facts?
There is a congenital disease called cretinism which essentially is due to a lack of thyroid secretion. This disease is particularly prevalent in Southern France, Spain, Upper Italy and Switzerland. It is characterized mainly by marked dwarfism and imbecility, so that the adult untreated cretin remains about as large as a three or four-year-old child and has the mental level about that of a child of the same age. But, this comparison as to intelligence is a gross injustice to the child, for it leaves out the difference in character between the child and the cretin. The latter has none of the curiosity, the seeking for experience, the active interest, the pliant expanding will, the sweet capacity for affection, friendship and love present in the average child.
The cretin is a travesty on the human being in body, mind and character.
But feed him thyroid gland. Mind you, the dried substance of the glands, not of human beings, but of mere sheep. The cretin begins to grow mentally and physically and loses to a large extent the grotesqueness of his appearance. He grows taller; his tongue no longer lolls in his mouth; the hair becomes finer, the hands less coarse, and the patient exhibits more normal human emotions, purposes, intelligence. True, he does not reach normality, but that is because other defects beside the thyroid defect exist and are not altered by the thyroid feeding.
There is a much more spectacular disease to be cited, --a relatively infrequent but well-understood condition called myxoedema, which occurs mainly in women and is also due to a deficiency in the thyroid secretion. As a result the patient, who may have been a bright, capable, energetic person, full of the eager purposes and emotions of life, gradually becomes dull, stupid, apathetic, without fear, anger, love, joy or sorrow, and without purpose or striving. In addition the body changes, the hair becomes coarse and scanty, the skin thick and swollen (hence the name of the disease) and various changes take place in the sweat secretion, the heart action, etc.
Then, having made the diagnosis, work the great miracle! Obtain the dried thyroid glands of the sheep, prepared by the great drug houses as a by-product of the butcher business, and feed this poor, transformed creature with these glands! No fairy waving a magical wand ever worked a greater enchantment, for with the first dose the patient improves and in a relatively short time is restored to normal in skin, hair, sweat, etc., and MIND and character! To every physician who has seen this happen under his own eyes and by his direction there comes a conviction that mind and character have their seat in the organic activities of the body,--and nowhere else.
An interesting confirmation of this is that when the thyroid is overactive, a condition called hyperthyroidism, the patient becomes very restless and thin, shows excessive emotionality, sleeplessness, has a rapid heart action, tremor and many other signs not necessary to detail here. The thyroid in these cases is usually swollen. One of the methods used to treat the disease is to remove some of the gland surgically. In the early days an operator would occasionally remove too, much gland and then the symptoms, of myxoedema would occur. This necessitated the artificial feeding of thyroid the rest of the patient's life!
With the proper dosage of the gland substance the patient remains normal; with too little she becomes dull and stupid; with too much she becomes unstable and emotional!
There are plenty of other examples of the influence of the endocrines on mind, character and personality. I here briefly mention a few of these.
In the disease called acromegaly, which is due to a change in the pituitary gland, amongst other things are noted "melancholic tendencies, loss of memory and mental and physical torpor."
